Smart Solutions for a Better Brain

Smart Solutions for a Better Brain

Do you ever feel like you’re walking around in a thick fog? Maybe you can’t recall the name of someone you’ve known for years…or you’re noticing that simple mental tasks take longer than they used to… 

While they might seem like no big deal, these seemingly minor brain slips may actually be the first signs of serious cognitive decline. And if you think you’re too young to start worrying about that, think again. 

Cognitive loss is on the rise. And it’s hitting younger and younger populations.  Yes, memory loss is a top symptom. But it can also show up with signs like: 

  • Being slower at normal tasks 
  • Trouble retaining new info 
  • Feeling overwhelmed with new information 
  • Difficulty focusing 

These and other related issues mean your brain needs support. They can also be early red flags signaling the development of Alzheimer’s disease or dementia down the road. 

Alarmingly, Alzheimer’s disease is skyrocketing in younger adults. For example, new diagnoses of Alzheimer’s has tripled in people under age 65 since 2013… In people aged 20-44, the disease has risen 373%. And in Americans aged 45-64,  58.7% reported difficulties due to cognitive problems.1,2 

Brain Drain #1: Toxins 

Your brain is particularly vulnerable to a wide range of common toxins you’re exposed to regularly.3 Some of the biggest culprits include heavy metals such as lead, cadmium, and mercury that show up in our food, water, and surrounding environments. These toxic metals can find their way into your brain and nervous system, trigger neuroinflammation and harm your cognitive function. 

Research shows a close link between toxic heavy metals and Alzheimer’s disease and dementia. These toxins can damage your brain in several ways:4,5 

  • increase the buildup of beta-amyloid plaque in the brain, a hallmark of Alzheimer’s disease 
  • increase the buildup of tau proteins, also shown to harm brain cells  
  • disrupt essential minerals for brain health 
  • interfere with neurotransmitter production 
  • trigger alarm protein called galectin-3 that causes neuro-inflammation 

Mycotoxins – poisons produced by mold – are also a problem for brain function and can play a role in Alzheimer’s.6  Mycotoxins can be found nearly everywhere,  from packaged foods to damp indoor environments. Many people have trouble naturally detoxifying mycotoxins, leading these harmful toxins to cause lasting harm to the brain and body. 

In today’s world, it’s practically impossible to avoid exposure to these and other toxins. And many researchers theorize that these common pollutants can accelerate Alzheimer’s disease—so it strikes younger, and progresses faster.7 

Your body has natural detox mechanisms, but we didn’t evolve to handle this level of exposure we face today. In my practice, I rely on natural detox agents that gently and effectively help to reduce toxic body burden of heavy metals, environmental toxins and other pollutants, to protect long-term health—including brain function.   

Brain Drain #2: Neuro-inflammation 

Inflammation inside the brain (neuro-inflammation) is a major contributor to cognitive loss, and other serious neurological conditions.8 To reduce neuro-inflammation, you need to address one of its primary triggers: alarm protein galectin-3.  

When the body is under stress, galectin-3 signals your immune system, ordering it to produce inflammation as a response. However, many times this inflammation can’t turn off on its own, and ends up harming the brain in various ways, such as:9,10 

  • destroying brain cells 
  • increasing oxidative stress and damage 
  • triggering brain fog and memory loss 
  • disrupting focus and attention 
  • increasing risks of dementia and Alzheimer’s disease 

In fact, researchers now theorize that galectin-3 plays a key role in Alzheimer’s… and that blocking it may counteract the formation and progression of this devastating neurological disease.11 

Galectin-3 Fuels Alzheimer’s Disease 

By triggering neuro-inflammation, galectin-3 sets off a cascade of biochemical reactions that can contribute to Alzheimer’s disease. The disease can progress slowly, and begin in the brain earlier in life than scientists realized, whittling away at brainpower in seemingly minor ways. Before you know it, these changes can accelerate into dementia.  

Studies show that Alzheimer’s disease patients have much higher levels of galectin-3 than healthy people. One study found elevated galectin-3 in patients with Alzheimer’s disease and patients with mild cognitive impairment, suggesting how the protein plays a role in the path to Alzheimer’s.12   

Another study showed that all subjects with Alzheimer’s had significantly higher levels of galectin-3.13 This finding led to the conclusion that galectin-3 testing could help identify Alzheimer’s in its beginning stages, while there’s still time to intervene.  

This is where a groundbreaking new study on the use of galectin-3 blockers in cognitive impairment becomes so significant. This new study included patients with type 2 diabetes and resulting mild cognitive impairment… and significantly higher levels of galectin-3. Diabetes is a well-known risk factor for dementia. In fact, Alzheimer’s disease has been referred to as Type 3 Diabetes because of the close connections between glucose imbalance, neuroinflammation and cognitive decline.  

In this groundbreaking new study, researchers showed that modified citrus pectin, the most-researched galectin-3 blocker, inhibited the actions of galectin-3 and reversed learning and memory problems in a type 2 diabetes animal model.14 

Smart Solutions for Better Clarity and Brain Power 

If you’ve been noticing an increase in memory lapses… difficulty concentrating… or other signs that your brain needs more power, these five strategies can offer targeted support. 

1. Clinically Researched Modified Citrus Pectin (MCP) 

MCP delivers multiple benefits for brain power, neurological health and overall wellness. Not only does this super nutrient safely remove heavy metals and other brain-harming toxins,15 it’s also the most-studied galectin-3 blocker.16 

By blocking galectin-3, MCP can help:17  

  • protect against memory loss 
  • improve cognitive function 

With over 60 published studies to date, MCP delivers a broad spectrum of powerful health benefits, including support against cancer and metastasis, cardiovascular and kidney disease, and general aging. Most of these benefits come from its unique ability to inhibit galectin-3 and support optimal healing and repair throughout the body.18 

2. Pure Honokiol Magnolia Bark Extract  

Pure honokiol is a powerful, multifunctional extract, with potent natural antioxidant and anti-inflammatory benefits. It is extensively researched for its neurological support and protection, and demonstrates targeted benefits for brain health and function. 

Studies show that honokiol can reduce neuroinflammation and protect against oxidative damage, offering vital protection for the brain. Pure honokiol has the unique ability to cross the blood-brain barrier and inhibit inflammatory compounds to fight cognitive decline.19-22 

Research also shows that honokiol and MCP work synergistically together. This strategic combination offers increased anti-inflammatory and antioxidant effects and delivers even more support and protection for cognitive function and overall health. 23 

3. Diet for a Better Brain  

The foods you eat have a direct effect on your brain. Research shows that foods high in antioxidant and anti-inflammatory compounds can support optimal cognitive function.  

Foods with specific brain-boosting properties include:,, 

  • raw nuts and seeds 
  • fresh berries 
  • fatty fish, such as salmon and sardines 
  • green vegetables 

4. Exercise 

One of the simplest and best ways to boost your cognitive function is with regular exercise. In fact, physical inactivity is a primary risk factor for Alzheimer’s disease… and on the positive side, regular physical activity may be one of the best interventions. Aerobic exercise and dance can be especially beneficial for improving brain function.  

5. Healthy Stress Relief 

Chronic stress floods your brain and nervous system with cortisol, the main stress hormone—with serious impacts to brainpower. Have you ever tried to think clearly under high stress? Even chronic, low-level stress can increase inflammation and drain your brain power.  

Meditation is one of the best methods for relieving stress and increasing brain power and executive function. One study found that even just 12 minutes a day of meditation could improve brain function and combat memory loss in subjects with mild cognitive impairment.   

Many people accept cognitive loss as a normal part of aging. But the truth is, “senior moments”—regardless of your age—are actually a sign that your brain and body could use some additional support. With these researched strategies, you can optimize your brain, and overall health, while you continue to make memories that last a lifetime.  

 
 Sources: 

  1. Early-Onset Dementia and Alzheimer’s Rates Grow for Younger American Adults, a Blue Cross Blue Shield Association (BCBSA) report. Published February 27, 2020. Accessed October 25, 2020. https://www.bcbs.com/the-health-of-america/reports/early-onset-dementia-alzheimers-disease-affecting-younger-american-adults 

  1.  Subjective Cognitive Decline – a Public Health Issue, Centers for Disease Control and Prevention. Reviewed July 30, 2019. Accessed October 24, 2020. https://www.cdc.gov/aging/aginginfo/subjective-cognitive-decline-brief.html 

  1.  Finch CE, Kulminski AM. The Alzheimer’s Disease Exposome. Alzheimer’s Dement. 2019 Sep;15(9):1123-1132.  

  1.  Bakulski KM, Seo YA, Hickman RC, et al. Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias. J Alzheimers Dis. 2020;76(4):1215-1242. doi:10.3233/JAD-200282 

  1.  Huat TJ, Camats-Perna J, Newcombe EA, Valmas N, Kitazawa M, Medeiros R. Metal Toxicity Links to Alzheimer’s Disease and Neuroinflammation. J Mol Biol. 2019 Apr 19;431(9):1843-1868.  

  1.  Bredesen DE. Inhalational Alzheimer’s disease: an unrecognized – and treatable – epidemic. Aging (Albany NY). 2016;8(2):304-313. doi:10.18632/aging.100896 

  1.  Vasefi M, Ghabolian-Zare E, Abedelwahab H, Osu A. Environmental Toxins and Alzheimer’s Disease Progression. Neurochem Int. 2020 Sep 30:104852. doi: 10.1016/j.neuint.2020.104852. Epub ahead of print.  

  1.  Bradburn S, Murgatroyd C, Ray N. Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis. Ageing Res Rev. 2019 Mar;50:1-8. doi: 10.1016/j.arr.2019.01.002. Epub 2019 Jan 2. PMID: 30610927. 

  1.  Liu FT, Hsu DK. The role of galectin-3 in promotion of the inflammatory response. Drug News Perspect. 2007 Sep;20(7):455-60. doi: 10.1358/dnp.2007.20.7.1149628. PMID: 17992268. 

  1.  Sartori AC, Vance DE, Slater LZ, Crowe M. The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research. J Neurosci Nurs. 2012;44(4):206-217. doi:10.1097/JNN.0b013e3182527690 

  1.  Boza-Serrano A, et al. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease. Acta Neuropathol. 2019 Aug;138(2):251-273.  

  1.  Wang X, Zhang S, Lin F, Chu W, Yue S. Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer’s Disease. Am J Alzheimers Dis Other Demen. 2015 Dec;30(8):729-32. 

  1.  Yazar, T., Olgun Yazar, H. & Cihan, M. Evaluation of serum galectin-3 levels at Alzheimer patients by stages: a preliminary report. Acta Neurol Belg (2020). https://doi.org/10.1007/s13760-020-01477-1 

  1.  Ma S, Li S, Lv R, Hou X, Nie S, Yin Q. Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin-3 level. J Diabetes Investig. 2020 Mar 20;11(5):1295–302. doi: 10.1111/jdi.13256. Epub ahead of print. PMID: 32196999; PMCID: PMC7477520. 

  1.  Eliaz I, Hotchkiss AT, Fishman ML, Rode D. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res. 2006 Oct;20(10):859-64. doi: 10.1002/ptr.1953. PMID: 16835878. 

  1.  Fang T, Liu DD, Ning HM, Dan Liu, Sun JY, Huang XJ, Dong Y, Geng MY, Yun SF, Yan J, Huang RM. Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3. Acta Pharmacol Sin. 2018 Dec;39(12):1885-1893. doi: 10.1038/s41401-018-0004-z. Epub 2018 May 16. PMID: 29769742; PMCID: PMC6289393 

  1.  Yin Q, Chen J, Ma S, Dong C, Zhang Y, Hou X, Li S, Liu B. Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro. J Inflamm Res. 2020 Sep 15;13:533-542. doi: 10.2147/JIR.S273858. PMID: 32982368; PMCID: PMC7508034. 

  1.  Eliaz I, Raz A. Pleiotropic Effects of Modified Citrus Pectin. Nutrients. 2019 Nov 1;11(11):2619. doi: 10.3390/nu11112619. PMID: 31683865; PMCID: PMC6893732. 

  1.  Zhang B, Wang PP, Hu KL, Li LN, Yu X, Lu Y, Chang HS. Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model. Molecules. 2019 May 28;24(11):2035. 

  1.  Guo S, Xu JJ, Wei N, Han JY, Xue R, Xu PS, Gao CY. Honokiol Attenuates the Memory Impairments, Oxidative Stress, Neuroinflammation, and GSK-3β Activation in Vascular Dementia Rats. J Alzheimers Dis. 2019;71(1):97-108.  

  1.  Rickert U, Cossais F, Heimke M, Arnold P, Preuße-Prange A, Wilms H, Lucius R. Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes. J Neuroimmunol. 2018 Oct 15;323:78-86. doi: 10.1016/j.jneuroim.2018.07.013. Epub 2018 Jul 25. PMID: 30196838. 

  1.  Woodbury A, Yu SP, Wei L, García P. Neuro-modulating effects of honokiol: a review. Front Neurol. 2013;4:130. Published 2013 Sep 11. doi:10.3389/fneur.2013.00130 

  1.  Ramachandran C, Wilk B, Melnick SJ, Eliaz I. Synergistic Antioxidant and Anti-Inflammatory Effects between Modified Citrus Pectin and Honokiol. Evid Based Complement Alternat Med. 2017;2017:8379843.