How Gum Disease Triggers Cancer, Heart Attacks, Obesity, and More—And How to Stop It

How Gum Disease Triggers Cancer, Heart Attacks, Obesity, and More—And How to Stop It

Do your gums bleed when you brush or floss? Do they look red or puffy? Are you concerned about loose teeth?  

If you answered yes to any of those questions, you’re one of the millions of people suffering from at least some degree of gum disease.  

And this problem doesn’t just stay in your mouth… 

Dental health connects to your whole-body health.1 If your teeth or gums are in bad shape, you’re much more likely to have other conditions or illnesses. There’s a growing stack of research linking poor dental health with serious – even deadly – health issues. 

Luckily, fixing your dental health can also improve your overall health, and maybe even save your life. Even better, you can get to the root of the problem without taking extra trips to the dentist. All you need is a 3-step rescue plan to keep your gums healthy and your teeth firmly in place.  

Gum Disease Raises Your Risk for Deadly Diseases 

Your mouth is full of bacteria – don’t worry, it’s supposed to be. Many of those are beneficial bacteria that help keep your mouth healthy, but some can be harmful, like the ones that cause or worsen gum disease.  

Those harmful bacteria trigger inflammation – one of the most important issues in dental health. Inflammation eats away at gum tissue and breaks down bone tissue, both of which hold your teeth in place. It’s a primary factor in gum disease, and the main factor that leads to system-wide health issues. 

Even a slight degree of gum disease opens the gateway for those oral bacteria to enter your bloodstream. And since dental issues tend to be chronic, that means those oral bacteria cause ongoing problems. When bacteria that belong in your mouth travel throughout your body, they can: 

  • infect other cells, tissues, and organs 
  • trick special immune cells (called TH17 cells) into protecting them 
  • block the killing power of immune cells 
  • increase the activity of inflammatory cells and compounds 

Chronic dental health problems lead to chronic inflammation in your body. That gets compounded when an alarm protein called galectin-3 gets activated. Galectin-3 keeps the inflammation cascade going and makes you much more vulnerable to all kinds of infectious and chronic diseases. 2  

Many Serious Health Problems Connect Back to Gum Disease 

As unbelievable as it sounds, problems in your mouth can lead to the most dreaded diseases… even premature death. And there are stacks upon stacks of research proving that connection.  

Scientific studies show clear links between poor dental health and higher risk of… 

  • Heart attack and stroke3 
  • Osteoporosis and bone loss4 
  • Alzheimer’s disease and cognitive decline5 
  • Rheumatoid arthritis6 
  • Diabetes7 
  • Autoimmune diseases8 
  • Lung diseases, including pneumonia and COPD9 
  • Cancer,, especially breast cancer 10-12 
  • Premature death13 

As frightening as that sounds, there’s good news here. Taking charge of your dental health can reverse gum disease… secure your teeth… and improve your overall wellness and vitality. 

Your 3-Step Dental Health Rescue Plan 

Dental health doesn’t improve overnight, especially if your gums have been inflamed and bleeding for a while. The sooner you get started with this 3-step rescue plan, the faster you’ll be able to brush and floss without discomfort. And as your dental health gets better, your overall health will bounce back, too. 

The 3-step approach offers both immediate and long-term support for your dental health. The plan starts by eliminating the harmful bacteria that both causes and worsens gum disease. In turn, that quiets down inflammatory compound and soothes puffy, painful gums. Over time, your teeth and gums will regain strength and resilience. That provides the triple benefit of preventing more bacteria from entering the bloodstream, protecting you against disease, and giving your whole body the opportunity to heal. 

Step 1: Honokiol Targets Infectious Microbes That Cause Gum Disease 

Honokiol, a compound extracted from magnolia bark, compound delivers strong antimicrobial and anti-inflammatory action – exactly what you need when you’re working to improve your dental health. In fact, a brand-new study – released September 2020 – concludes that honokiol has the potential to “cure or fight oral diseases.”14 

This powerful natural plant extract successfully fights the bacteria that cause gum disease,15 including: 

  • Actinobacillus actinomycetemcomitans 
  • Porphyromonas gingivalis 
  • Prevotella intermedia 
  • Micrococcus luteus 
  • Streptococcus mutans 

Recent research shows that honokiol helps prevent tooth decay.16 And while researchers are trying to develop effective drugs to fight oral bacteria using honokiol as their model,17 they’ll never work as well as nature’s version. In addition to fighting the bacteria that cause gum disease, honokiol calms inflammation,18,19 – and that helps reduce the pain of sore gums. 

Honokiol’s benefits don’t stop at your gum line. This herbal treasure also helps fight many inflammation-related diseases, including: 

  • Cancer20 
  • Alzheimer’s disease21 
  • Diabetes22  

So while you’re healing your gums and protecting your teeth, you’ll also be safeguarding your overall health with honokiol. 

Step 2: Tibetan Herbal Formula Heals Inflamed Gums and Protects Teeth 

This time-honored herbal remedy is based on a traditional “cooling” Tibetan formula, and studied through decades of clinical research. The 19 botanical ingredients in this formula work together through the principles of Tibetan medicine to combat “heat” and revitalize circulation by “moving wind.”  

Those properties allow this formula to: 

  • Calm painful inflammation 
  • Reduce damaging oxidative stress 
  • Boost immune function 
  • Fight infectious microbes 
  • Support healthy blood flow  

All of those actions can help significantly improve dental health… and that includes helping you avoid dreaded root canals. 

Importantly, a clinical study23 found that this formula effectively treated toothaches caused by chronic dental pulpitis, where the pulp of the tooth becomes inflamed and painful. The formula worked so well that:  

  • 55% of patients were pain-free within 1 month 
  • 81% became pain-free in 2 to 3 months 
  • 24% remained free of dental pain for more than 3 years 

Best of all, those patients were able to avoid root canals and tooth extractions after using this classical Tibetan formula.  

Step 3: Modified Citrus Pectin Halts Inflammation Triggered by Gum Disease 

Modified citrus pectin, or MCP, starts out as citrus pith and transforms into a powerful ally that fights disease on the cellular level. MCP blocks galectin-3,24 the alarm protein that triggers widespread inflammation at the root of many chronic conditions.25  By stopping galectin-3, MCP can help relieve inflamed gums, which has the extra effects of keeping your teeth in place and closing the gateway that allows oral bacteria to infect other areas of the body.  

At the same time it’s taming galectin-3 and inflammation, MCP also supports immune system function. It activates critical immune cells and increases their fighting abilities.26 That can help kill off the pathogens that cause gum disease.  

And like honokiol, MCP’s superpowers extend far beyond dental health. MCP offers dozens of health benefits, from detoxing heavy metals to fighting cancer to protecting against heart attack and stroke.27  

As researchers continue to explore the system-wide impacts of gum disease and oral health, experts estimate that your dentist may help play a key role in preventative care, highlighting potential long-term health risks early enough to address a wide range of chronic and life-threatening conditions.  

Sources: 

  1.  Kane SF. The effects of oral health on systemic health. Gen Dent. 2017 Nov-Dec;65(6):30-34. PMID: 29099363. 

  1. Kara C, Çelen K, Dede FÖ, Gökmenoğlu C, Kara NB. Is periodontal disease a risk factor for developing severe Covid-19 infection? The potential role of Galectin-3. Exp Biol Med (Maywood). 2020 Oct;245(16):1425-1427. doi: 10.1177/1535370220953771. Epub 2020 Aug 24. PMID: 32838557. 

  1.  Lee HJ, Choi EK, Park JB, Han KD, Oh S. Tooth Loss Predicts Myocardial Infarction, Heart Failure, Stroke, and Death. J Dent Res. 2019 Feb;98(2):164-170. doi: 10.1177/0022034518814829. PMID: 30782090. 

  1.  Huang YF, Chang CT, Liu SP, et al. The Impact of Oral Hygiene Maintenance on the Association Between Periodontitis and Osteoporosis: A Nationwide Population-Based Cross Sectional Study. Medicine (Baltimore). 2016;95(6):e2348. doi:10.1097/MD.0000000000002348 

  1.  Teixeira FB, Saito MT, Matheus FC, Prediger RD, Yamada ES, Maia CSF, Lima RR. Periodontitis and Alzheimer’s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation. Front Aging Neurosci. 2017 Oct 10;9:327. doi: 10.3389/fnagi.2017.00327. PMID: 29085294; PMCID: PMC5649154. 

  1.  de Molon RS, Rossa C Jr, Thurlings RM, Cirelli JA, Koenders MI. Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions. Int J Mol Sci. 2019 Sep 13;20(18):4541. doi: 10.3390/ijms20184541. PMID: 31540277; PMCID: PMC6769683. 

  1.  Preshaw PM, Alba AL, Herrera D, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21-31. doi:10.1007/s00125-011-2342-y 

  1. Rutter-Locher Z, Fuggle N, Orlandi M, et al.Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology. Intechopen. 2017. DOI: 10.5772/intechopen.69012 

  1.  Bansal M, Khatri M, Taneja V. Potential role of periodontal infection in respiratory diseases – a review. J Med Life. 2013;6(3):244-248. 

  1.  Rajesh KS, Thomas D, Hegde S, Kumar MS. Poor periodontal health: A cancer risk?. J Indian Soc Periodontol. 2013;17(6):706-710. doi:10.4103/0972-124X.124470 

  1.  Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L Giovannucci, Andrew T Chan, Mingyang Song. Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study. Gut, 2020; gutjnl-2020-321949 DOI: 10.1136/gutjnl-2020-321949 

  1.  Shao J, Wu L, Leng WD, et al. Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants. Front Oncol. 2018;8:601. Published 2018 Dec 12. doi:10.3389/fonc.2018.00601 

  1.  Söder B, Jin LJ, Klinge B, Söder PO. Periodontitis and premature death: a 16-year longitudinal study in a Swedish urban population. J Periodontal Res. 2007 Aug;42(4):361-6. doi: 10.1111/j.1600-0765.2006.00957.x. PMID: 17559634. 

  1.  Chiu KC, Shih YH, Wang TH, Lan WC, Li PJ, Jhuang HS, Hsia SM, Shen YW, Yuan-Chien Chen M, Shieh TM. In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages. J Formos Med Assoc. 2020 Sep 23:S0929-6646(20)30425-3. doi: 10.1016/j.jfma.2020.09.002. Epub ahead of print. PMID: 32978046. 

  1.  Ho KY, Tsai CC, Chen CP, Huang JS, Lin CC. Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytother Res. 2001 Mar;15(2):139-41. doi: 10.1002/ptr.736. PMID: 11268114. 

  1.  Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y. Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans. Microbiol Immunol. 2016 Jan;60(1):10-6. doi: 10.1111/1348-0421.12343. PMID: 26600203. 

  1.  Solinski AE, Ochoa C, Lee YE, Paniak T, Kozlowski MC, Wuest WM. Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria. ACS Infect Dis. 2018;4(2):118-122. doi:10.1021/acsinfecdis.7b00178 

  1.  Khalid S, Ullah MZ, Khan AU, et al. Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling. Front Pharmacol. 2018;9:140. Published 2018 Mar 20. doi:10.3389/fphar.2018.00140 

  1.  Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T. Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. Inflammation. 2018 Dec;41(6):2110-2115. doi: 10.1007/s10753-018-0854-z. PMID: 30039429. 

  1.  Rauf A, Patel S, Imran M, Maalik A, Arshad MU, Saeed F, Mabkhot YN, Al-Showiman SS, Ahmad N, Elsharkawy E. Honokiol: An anticancer lignan. Biomed Pharmacother. 2018 Nov;107:555-562. doi: 10.1016/j.biopha.2018.08.054. Epub 2018 Aug 13. PMID: 30114639. 

  1.  Talarek S, Listos J, Barreca D, Tellone E, Sureda A, Nabavi SF, Braidy N, Nabavi SM. Neuroprotective effects of honokiol: from chemistry to medicine. Biofactors. 2017 Nov;43(6):760-769. doi: 10.1002/biof.1385. Epub 2017 Aug 17. PMID: 28817221. 

  1.  Kim YJ, Jung UJ. Honokiol Improves Insulin Resistance, Hepatic Steatosis, and Inflammation in Type 2 Diabetic db/db Mice. Int J Mol Sci. 2019 May 9;20(9):2303. doi: 10.3390/ijms20092303. PMID: 31075962; PMCID: PMC6540170. 

  1.  Füllemann F. Padma 28 in der Behandlung von chronischen Zahnpulpitiden: Eine Praxisbeobachtung an 49 Fällen [Padma 28 in the treatment of chronic dental pulpitis: an observational case study in 49 patients]. Forsch Komplementmed. 2006 Feb;13 Suppl 1:28-30. German. 

  1.  Fang T, Liu DD, Ning HM, et al. Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3. Acta Pharmacol Sin. 2018;39(12):1885-1893. doi:10.1038/s41401-018-0004-z 

  1.  Sciacchitano S, Lavra L, Morgante A, Ulivieri A, Magi F, De Francesco GP, Bellotti C, Salehi LB, Ricci A. Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z. Int J Mol Sci. 2018 Jan 26;19(2):379. doi: 10.3390/ijms19020379. PMID: 29373564; PMCID: PMC5855601. 

  1.  Ramachandran C, Wilk BJ, Hotchkiss A, Chau H, Eliaz I, Melnick SJ. Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin. BMC Complement Altern Med. 2011;11:59.  

  1.  Eliaz I, Raz A. Pleiotropic Effects of Modified Citrus Pectin. Nutrients. 2019;11(11):2619. Published 2019 Nov 1. doi:10.3390/nu11112619