Study: Modified Citrus Pectin Makes Chemo Safer and Stronger

Study: Modified Citrus Pectin Makes Chemo Safer and Stronger

Research shows Modified Citrus Pectin makes lower chemotherapy doses work better.

This is important news because when it comes to cancer prevention and treatment, a strategic combination of diverse, integrative approaches might mean the difference between life and death. In fact, research published in the journal Cell Biology International suggests just that. The study analyzed a combination of Modified Citrus Pectin and the chemotherapy drug Doxorubicin, and found that using the two compounds together dramatically increased their anti-cancer effects, in this case against prostate cancer.

The Value of Combined Synergy

As an integrative physician, I rely on strategic combinations of the best treatments suited to an individual’s unique needs and requirements. In some cases, this involves the use of certain pharmaceutical compounds which can be more effective and less toxic when combined with specific natural therapies. This published study is an excellent example of such synergy, and highlights a key strategy in successful integrative cancer therapy.

Doxorubicin: The Red Devil

Doxorubicin (Dox) is an effective anti-cancer drug, but it’s also one of the most toxic. Nicknamed “The Red Devil” or “Red Death” for its serious side effects, Dox can cause severe heart and immune damage among other complications. The doses needed to impact tumors are not well tolerated by patients; however, researchers may have found an answer with this latest study.

Results demonstrated that combining Dox with Modified Citrus Pectin (MCP) increased the anti-cancer activity of Dox. This finding bodes well for prostate cancer patients, especially those too weak for normal chemotherapy regimens. Combination therapy using MCP may allow for lower doses of Dox with greater clinical impact and reduced toxicity.

Dox with Modified Citrus Pectin

The study tested whether combining Dox with MCP would increase effectiveness against prostate cancer cells in vitro. It did, significantly. The team used two forms of prostate cancer: Androgen-dependent (LNCaP) and androgen-independent (DU-145). The results were impressive, as the combination treatment reduced cancer cell viability by more than 67 percent in both types. Specifically, the researchers were looking at the cell cycle, the cell division process and apoptosis—the programed cell death mechanisms which destroy abnormal cells and are often impaired in cancers.

Important News for Prostate Cancer

This study demonstrates that MCP enhances the cytotoxic effect of Doxorubicin in both androgen-dependent but more importantly in androgen-independent prostate cancer. This is especially important because prostate cancer patients who do not respond to hormone therapy and require chemotherapy are often the most in need of advanced treatments.

Androgen-dependent prostate cancer is often treated by depriving it of hormones. Androgen-independent prostate cancers no longer respond to hormone therapy, having developed new mechanisms to grow and thrive. The combination treatment worked against the androgen-dependent form by shutting down the cell cycle. The treatment killed the androgen-independent cells by boosting apoptosis.

Ongoing Modified Citrus Pectin Cancer Research

This is one of the latest in a series of studies that have substantiated MCP’s ability to fight cancer. As early as 1995, a study by researchers at Wayne State University found that MCP inhibited metastasis to the lungs in animals with prostate cancer. A phase I clinical trial in 1997 and a phase II clinical trial published in 2003, showed MCP slowed cancer growth in human subjects. A study in 2007 at Albert Ludwigs University in Germany found clinical benefit for advanced cancer patients receiving MCP treatment. And a study in 2010, conducted at Columbia University, showed MCP induces apoptosis and reduces proliferation in aggressive cancer.

MCP: The only proven Galectin-3 blocker

The powerful cancer-fighting abilities of MCP have attracted the attention of researchers and doctors around the world. MCP’s most significant anti-cancer function comes from its unique ability to disarm the dangerous Galectin-3 molecule. Decades of research show that excess Galectin-3 in the body fuels the growth and metastasis of cancer and makes the disease more aggressive. MCP is thus earning a prestigious reputation as the only natural compound proven to enter the blood stream and bind to excess Galectin-3 molecules, blocking their disease-causing effects. Furthermore, as a versatile natural therapy, MCP supports other angles of cancer prevention and treatment. MCP is proven to provide dramatic benefits for immune health; reduce chronic inflammation and safely remove heavy metals from the body.

Successful Integrative Medicine

The ability of such a safe supplement to decrease the needed dosage of Doxorubicin is very significant. Combination therapy using MCP allows lower levels of Doxorubicin to be used with greater effect on inducing rapid cell death in the hard-to-treat androgen-independent prostate cancer, and halting the viability of the androgen-dependent prostate cancer. The lower doses and increased effectiveness are a win-win.

This type of synergistic strategy is an excellent example of successful integrative medicine hard at work to fight disease, while simultaneously promoting the health of the patient with targeted, scientifically substantiated natural solutions.

Link to the Study:  Combination effect of PectaSol and Doxorubicin on viability, cell cycle arrest and apoptosis in DU-145 and LNCaP prostate cancer cell lines. Cell Biol Int. 2012 Jan 4. [Epub ahead of print].

To read about the MCP supplement that I most recommend, click here.

Your Thoughts
What do you think about this article? Please share your thoughts and experiences in the comments section below. We love to read your feedback!

There are 30 comments for this article
  1. dianne perkins at 7:36 am

    This is exactly the kind of information that cancer patients need to face treatment with hope rather than dread. Now let’s see whether modified citrus pectin enhances the efficacy of taxol and carboplatin–an often prescribed chemo regimen for lung and gynecological cancers.

    Can you get the funding for such further studies?

  2. Philip Flournoy at 8:24 am

    MCP with Vit D3 and Low Dose Naltrexone quickly put my prostate cancer in remission. A great product.

  3. Dr. Betty Gaw at 12:21 pm

    What is the daily dose of MCP for men of 135, 180, 200 pound weights? What times of the day to take it, with or without food?

  4. admin at 2:09 pm

    Dear Dr. Gaw,

    The clinically researched recommended dose of MCP is 15 grams per day, and is based on an average adult weight of 150 lbs. Therefore, you could say that for every 50 lbs. you can take 5 grams of MCP. However, please be aware that at doses higher than 15 grams, some people report minor stomach discomfort. For someone weighing 135 lbs., 15 grams is still the recommended dose.

    We hope this helps. Thank you for your question!

    The Blog Staff

  5. admin at 3:38 pm

    Our research department had this to say: “Epirubicin is an anthracycline drug, like the drug in the study, doxorubicin, which showed a synergistic effect with MCP in increasing the effect of the drug and reducing the side effects. So yes, it could show similar effects with the less toxic epirubicin. Epirubicin has a different spatial orientation in its molecular structure than doxorubicin, which account for its faster elimination and reduced toxicity, but should yield the same synergistic effect (with MCP) that trigger mechanisms that lead to cancer cell death.”

    Thank you for your comment!

  6. S. Pete Salierno at 12:45 pm

    Will MCP be helpful with the drug Rituximab being use for infusion for low-grade B cell Lymphoma, FLIPI grade 3 (high risk). I been on Rituxumab tratmwent for four weeks in January 2011 with some 50% reduction results showing on pet scans. I will again be starting a four week treatment at the end of this August.

    I have been taking MCP on and off for over 10 years for prostrate cancer. With no other treatments but natural products my last PSA reading May 22, 2012 showed a drop from 12.2 to 4.4 a near 8 point drop over three month period.My hope is takeing MCP with this secomd round treatment for Lymphoma could help this drug. Any information known would be appreciated……Thanks

  7. Khaled at 6:11 am


    My name is Khaled, I’m living in Finland. Couple of months ago my wife was diagnosed by breast, lymphic, lungs and liver cancers. I read in many articles that coffee enema is critical for cancer patient specially liver cancer. but I read in others that coffee enema is dangerous and must not be used. I’d like to know Dr. Eliaz’s opinion in this issue.

    Thanks & BR, Khaled.

  8. Ed at 5:52 pm

    Have seen much of a synergistic effect between Vitamin D3 blood level normalized to 60 ng/ml when used with MCP ? Wondering ??????????????????????

  9. Dorothy at 9:25 pm

    Diagnosed with multiple myeloma in 3/2011. Had radiation and chemo, and a stem cell transplant in Sept. 2011. In complete remission. WBC was in normal range (6.1) from Nov.2011 to Feb. 2012. Placed on 15 mgs. Revlimid maintenance, and in March 2011, WBC, started to decrease. Was then placed on 10 mgs. and in April, WBC decreased again. For two more months the dose was down to 5mgs. and the count went to 2.8, the first month, and 1.8 the next. Neutrophils were low so I was given a Neupogen shot, and off the 5 mgs.revlimid for two weeks. Just had another WBC taken and it went up to 2.2, and Absolute Neutrophil 800, Hgb 11.4, and plts. normal at 275,000. I was told to stay off the revlimid for another 2 weeks, and have another WBC then. If the WBC is still low then, a bone marrow biopsy will be done to determine why it continues to be low. Will the Mod. Citrus Pectin help increase the WBC? Is it safe with Revlimid? Thank You!

  10. Jane at 5:49 am

    How does MCP work with Xeloda? I am currently taking Xeloda for colon cancer. I am a
    stage IV colon cancer patient. Fatigue and nausea are the worst of the side effects, will MCP address these issues?

  11. admin at 11:28 am

    Dear Jane,

    MCP has not been studied for its effects with Xeloda, however it has been shown to support chemotherapeutics. MCP has not been shown to help with nausea or fatigue, but should not increase these issues.


    Dr. Eliaz Blog Staff

  12. admin at 10:31 am

    Dear Dorothy,

    MCP is not known to increase WBC counts. MCP does not have any known contraindications, but due to its ability to bind it is recommended to take other medication separate from MCP by two hours.

    We wish you the best of luck with your treatment. Please let us know if you need any further information.


    The Dr. Eliaz Blog Staff

  13. admin at 11:39 am

    Hello Ed,

    We have not seen or looked at the effect of MCP on Vitamin D3 blood levels, but due to its ability to bind it is recommended to take other medications and supplements separate from MCP by two hours.

    Best of luck to you!


    The Dr. Eliaz Blog Staff

  14. Hoda at 11:19 am

    I have been taking PectaSol C for almost 2 years (Breast IDC 3N). First I was advised to take 1 – 800mg cap a day while I was going through treatment. My intuition told me to switch to the powder form and now I take 5g/day as maintenance, when I remember, between meals! Since I have a hectic supplement schedule it’s hard to remember to fit it in every day. Am considering upping he dose to 10g, since I still have circulating tumor cells (per German blood test).

  15. betty lamm at 3:25 pm

    I have mcp on the label it says conains lead. Why would it contain lead?

  16. Rebecca Stacy at 3:42 am

    Dear Sir,
    My sister had a very large malignant tumor removed in November. The tumor location was at the bottom of the small intestine just before it emptying into the colon. It has spread to the lymph glands. She has had c.diff twice since then. In Jan. she was too weak for Chemotherapy to start. This treatment will start soon.
    I am seeking complimentary treatment to help with negative side effects of chemo and to strengthen her system.

  17. Staff at 11:07 am

    The lead mentioned in the label is required in California under prop 65 even if it is naturally occurring. MCP contains 0.05 parts per million of naturally occurring lead.

  18. Staff at 4:32 pm

    We are so sorry to hear of your sister’s situation. The complementary supplements suggested are: MCP (modified citrus pectin), Honokiol and medicinal mushrooms.

  19. shirley frojmovich at 7:15 am

    I would like to know it MCP is advisable for those with limited kidney function. Thank you.

  20. Staff at 4:21 pm

    Due to the amount of potassium contained in MCP, if you have kidney issues, you are advised to discuss this with your personnel health care practitioner, as this might be a cause for concern. The amount of both sodium and potassium per serving is listed on the container, so your provider should be able to use that information.

  21. Cora Tenebruso at 9:43 pm

    Though chemotherapy is an effective way to treat many types of cancer, chemotherapy treatment also carries a risk of side effects. Some chemotherapy side effects are mild and treatable, while others can cause serious complications. ::*’

    Kindly visit our blog page as well

  22. Carol LeBlanc at 5:34 pm

    I have been taking 2 of the Detox pills daily. Since the recommended anount is different on your other products I need to know if it is equivalent to your maintenance daily dose. I am so impressed with your products and have had great results with the Defense also. Thank You so much for making them available.

  23. Staff at 2:54 pm

    You are correct 2 capsules is the daily maintenance dosage.

    -Dr. Eliaz Staff

  24. Richard Renfield at 12:07 pm

    It is interesting to learn of the synergy between Dox and MCP. I know how difficult it is to obtain funding for research that does not involve a drug, but it would be even more interesting to know the impact of MCP on these cancers without any accompanying pharmaceutical, compared to the impact of the synergistic duo, as measured by short-term and long-term patient outcomes.

  25. Staff at 10:28 am

    Thank you for your comments. I will see that you are provided with our research data sheet so you can do further reading on the studies that have been done thus far on anticancer effects of MCP. Human studies that would have an MCP only arm would not be approved, since chemotherapy is the standard of care for cancer; so a combined MCP/chemo vs chemo only, would be the only way this could be accomplished. There have been limited studies of MCP in advanced cancer patients with benefits found for QOL and disease stabilization. (Azemar), MCP also increased the doubling time of the PSA in pts. of prostate cancer (Guess). You will find these and other studies in the handout we will send.

  26. Paulette Simpson at 8:12 am

    My sister was diagnosed with lung cancer in October of last year. It has spread to the kidneys, stomach and possibly the size of a pin tip in her brain. Last week the doctor ended chemo because of the damage and amount of bleeding it caused. Which of the products should she use and at what amounts. Please help us.

  27. admin at 5:19 pm

    We are very sorry to hear that your sister is so ill. We are not able to make personal medical recommendations to individuals on this website. In terms of supporting cellular health and immune function, Dr Eliaz recommends several compounds that have powerful benefits. Modified citrus pectin is well researched for these benefits; medicinal mushroom combinations have been used for immune support and longevity for thousands of years. Honokiol, an extract of magnolia bark, is demonstrating powerful cellular health benefits in preclinical studies. Please see the research section of this website for more specific research on these compounds.

    You might also be interested to know that Dr. Eliaz maintains an active clinical practice in Santa Rosa, CA where he sees people from all over the world for integrative care for cancer and other serious illnesses. You can find out more information by going to

    We wish you and your sister all the best,

  28. Garvan F. Kuskey, DDS at 3:21 pm

    Some recommend MCP with meals, others recommend taking it on an empty stomach. Is there published science that establishes which mode provides for better absorption?
    Also, I’d appreciate your sending me your list of scholarly articles on MCP, especially as an adjunct to cancer therapy. Thank you!

  29. Staff at 2:22 pm

    Thank you for your questions. We recommend taking MCP on an empty stomach at least a half hour prior to food or 2 hours after. It can also be taken with tea or juice. Active dose is 5 grams or 1 scoop three times per day.
    Please visit research section for more nformation on MCP. All the best to you.