Modified Citrus Pectin Research
Modified Citrus Pectin for Cancer Support
PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen-Dependent and -Independent Prostate Cancer Cells
Modified Citrus Pectin Slows PSA Doubling Time: A Pilot Clinical Trial
Fighting Cancer Metastasis and Heavy Metal Toxicities With Modified Citrus Pectin
Clinical Benefit in Patients with Advanced Solid Tumors Treated with Modified Citrus Pectin: A Prospective Pilot Study
Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model
Modified Citrus Pectin Induces Cytotoxicity Of Prostate Cancer Cells In Cocultures With Human Endothelial Monolayers
Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice.
Changes in cell growth, cyclin/kinase, endogenous phosphoproteins and nm23 gene expression in human prostatic JCA-1 cells treated with modified citrus pectin.
Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin.
Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions.
Expression of galectin-3 in liver metastasis of colon cancer and the inhibitory effect of modified citrus pectin
Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin.
Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
Recognition of galactan components of pectin by galectin-3.
Modified Citrus Pectin for Heavy Metal Chelation and Detoxification
The Role Of Modified Citrus Pectin As An Effective Chelator Of Lead In Children Hospitalized With Toxic Lead Levels
Integrative Medicine and the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation and Detoxification – Five Case Reports
The Effect of Modified Citrus Pectin on Urinary Excretion of Toxic Elements
Modified Citrus Pectin Decreases the Total Body Burden of Mercury: A Pilot Human Clinical Trial
Improvement in Survival after Paraquat Ingestion Following Introduction of a New Formulation in Sri Lanka
Enhancement in fecal excretion of dioxin isomer in mice by several dietary fibers
Thermodynamic approach to the selection of polyuronide sequestrants for protection of the human body from toxic metal ions. Interactions of polyuronides with lead ions
Thermodynamic approach to the selection of polyuronide sequestrants for preventive and medicinal nutrition.
Medicinal Mushrooms Research
Medicinal Mushrooms and Immune Enhancement
Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity.
Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.
Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?
Gandoderma lucidum extract promotes immune responses in normal BALB/c mice In vivo.
Enteric mucosal immune response might trigger the immunomodulation activity of Ganoderma lucidum polysaccharide in mice.
Ganoderma lucidum induces the expression of CD40/CD86 on peripheral blood monocytes.
An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways.
Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells.
Immunopotentiation and anti-tumor activity of carboxymethylated-sulfated beta-(1-->3)-d-glucan from Poria cocos.
A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages.
Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction.
Fu-Ling, a Chinese herbal drug, modulates cytokine secretion by human peripheral blood monocytes.
Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB.
Activation of innate immunity to reduce lung metastases in breast cancer.
Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture.
Activation of macrophages and the intestinal immune system by an orally administered decoction from cultured mycelia of Cordyceps sinensis.
Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis.
Characterization and cytokine stimulating activities of heteroglycans from Tremella fuciformis.
Cytotoxic Steroids from Polyporus umbellatus.
New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus.
Inhibitory effects of triterpenes isolated from Chuling (Polyporus umbellatus Fries) on free radical-induced lysis of red blood cells.
Immunomodulatory effects of polysaccharopeptide (PSP) in human PBMC through regulation of TRAF6/TLR immunosignal-transduction pathways.
Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways.
Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity.
Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.
Lentinus edodes: A Macrofungus with Pharmacological Activities.
Study on immunostimulating activity of macrophage treated with purified polysaccharides from liquid culture and fruiting body of Lentinus edodes.
Lentinula edodes (Shiitake) mushroom extract protects against hydrogen peroxide induced cytotoxicity in peripheral blood mononuclear cells.
Structural characteristics of immunostimulating polysaccharides from lentinus edodes.
The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses.
Effect of Auricularia auricula polysaccharide on PBMCs proliferation and cytokine expression in vitro
Antioxidant and nitric oxide synthase activation properties of Auricularia auricula.
Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus.
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.
Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp.
Immunomodulatory function of polysaccharide of Hericium erinaceus
Beta-glucans in higher fungi and their health effects.
beta-glucan from Saccharomyces cerevisiae as a blood platelet antioxidant.
Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae.
Medicinal Mushrooms for Chronic Disease
Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells.
Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains.
Immunomodulatory effects of polysaccharopeptide (PSP) in human PBMC through regulation of TRAF6/TLR immunosignal-transduction pathways.
Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1.
Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy.
The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis.
A protein-bound polysaccharide, PSK, enhances tumor suppression induced by docetaxel in a gastric cancer xenograft model.
Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: in vitro and in vivo study.
Purinergic effects of a hydroalcoholic Agaricus brasiliensis (A. blazei) extract on liver functions.
Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells.
An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro.
A low molecular weight polysaccharide isolated from Agaricus blazei Murill (LMPAB) exhibits its anti-metastatic effect by down-regulating metalloproteinase-9 and up-regulating Nm23-H1.
Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice.
Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice.
Agaricus blazei Extract Induces Apoptosis through ROS-dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-{kappa}B in THP-1 Cells.
Anti-inflammatory activity of aqueous and alkaline extracts from mushrooms (Agaricus blazei Murill).
An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy.
Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo.
Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB.
Effects of the acid polysaccharide fraction isolated from a cultivated Cordyceps sinensis on macrophages in vitro.
Effect of Cordyceps Cinensis extractant on apoptosis and expression of Toll-like receptor 4 mRNA in the ischemia-reperfusion injured NRK-52E cells.
Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis.
Activation of innate immunity to reduce lung metastases in breast cancer.
Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells.
Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice.
Immunological alterations in lupus-prone autoimmune (NZB/NZW) F1 mice by mycelia Chinese medicinal fungus Cordyceps sinensis-induced redistributions of peripheral mononuclear T lymphocytes.
Apoptosis-inducing effects of sterols from the dried powder of cultured mycelium of Cordyceps sinensis.
Cytotoxic Steroids from Polyporus umbellatus.
New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus.
Inhibitory effects of triterpenes isolated from Chuling (Polyporus umbellatus Fries) on free radical-induced lysis of red blood cells.
Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production.
Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression.
Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells.
Immunomodulatory properties of Grifola frondosa in submerged culture.
Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa.
Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.
Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro.
Can maitake MD-fraction aid cancer patients?
beta-glucan from Saccharomyces cerevisiae as a blood platelet antioxidant.
Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae.
Research on Tibetan Herbal Medicine
PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids.
Treating intermittent claudication with Tibetan medicine Padma 28: does it work?
Padma 28 in the treatment of chronic dental pulpitis: an observational case study in 49 patients
Efficacy and safety of Padma 28 in peripheral arterial occlusive disease
Anti-inflammatory mechanisms of the Tibetan herbal preparation Padma 28 in the vessel wall.
Anti-inflammatory potential of Padma 28--review of experimental data on the antiatherogenic activity and discussion of the multi-component principle
Tibetan medicine in Europe: historical, practical and regulatory aspects
Apoptosis induced by the Tibetan herbal remedy PADMA 28 in the T cell-derived lymphocytic leukaemia cell line CEM-C7H2.
Complementary therapies for peripheral arterial disease: systematic review.
PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I.
Effects of the Tibetan herbal preparation PADMA 28 on blood lipids and lipid oxidisability in subjects with mild hypercholesterolaemia.
PADMA 28: a multi-component herbal preparation with retinoid-like dermal activity but without epidermal effects.
PADMA-28, a Tibetan herbal preparation is an inhibitor of inflammatory cytokine production.
PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro.
Comparative investigation of the antimicrobial activity of PADMA 28 and selected European herbal drugs.
Current Complementary and Alternative Therapies for Multiple Sclerosis.
Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line.
Anti- and pro-oxidative properties of PADMA 28, a Tibetan herbal formulation.
The effect of Padma-28, a traditional Tibetan herbal preparation, on human neutrophil function.
Padma-28, a herbal preparation, increases walking distance in patients with intermittent claudication
A botanical compound, Padma 28, increases walking distance in stable intermittent claudication.
Padma 28 modifies immunological functions in experimental atherosclerosis in rabbits.
Treatment of chronic ischemia of the lower extremities with complex herbal preparation
Research on Cardiovascular and Circulatory Disease
Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects.
Dietary supplementation with fermented soybeans suppresses intimal thickening.
Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat.
Effects of nattokinase on blood pressure: a randomized, controlled trial.
Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity.
Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters.
Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet.
A study of the comparative effects of hawthorn fruit compound and simvastatin on lowering blood lipid levels.
Effect of shanzha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet.
Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo.
Hawthorn extracts inhibit LDL oxidation.
Hawthorn: pharmacology and therapeutic uses.
Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia Miltiorrhiza.
Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet.
Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.
Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence: a controlled pilot study.
Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action.
Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps sinensis.
Pharmacological actions of Cordyceps, a prized folk medicine.
Cordycepin attenuates neointimal formation by inhibiting reactive oxygen species-mediated responses in vascular smooth muscle cells in rats.
L: -carnitine modulates blood platelet oxidative stress.
L-carnitine supplementation: influence upon physiological function.
L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients.
The role of carnitine and carnitine supplementation during exercise in man and in individuals with special needs.
Breast Cancer Research
Effects of quercetin on proliferation, apoptosis, adhesion and migration, and invasion of HeLa cells.
AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin.
Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells.
Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells.
Quercetin induces gadd45 expression through a p53-independent pathway.
Effects of quercetin on the proliferation and apoptosis in transplantation tumor of breast cancer in nude mice
Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin.
The effect of flavonoid derivatives on doxorubicin transport and metabolism.
Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells.
Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells.
Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines.
Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer.
Targeting breast stem cells with the cancer preventive compounds curcumin and piperine.
Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts.
Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer.
Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion.
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells.
Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription.
New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.
A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.
In vitro and in vivo anti-tumor effects of Astragalus membranaceus.
A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer.
Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells.
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer.
Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549.
Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells.
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.
Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27kip.
Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells.
Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells.
Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells.
Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30.
Differential anti-tumor activity of coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells.
Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling.
Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling.
Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling.
Ganoderma lucidum (Reishi) in cancer treatment.
Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells.
Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell.
Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells.
Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling.
Digestive Health Research
Effects of chromium picolinate on food intake and satiety.
A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving.
Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial.
Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.
Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia.
Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models.
Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis.
Anti-Obesity and Hypolipidemic Effects of Ethanolic Extract from Alpinia officinarum Hance (Zingiberaceae) in Rats Fed High-Fat Diet.
Antioxidative compounds isolated from the rhizomes of smaller galanga (Alpinia officinarum Hance).
Antiemetic principles of Alpinia officinarum.
Extracts of spice and food plants from Thai traditional medicine inhibit the growth of the human carcinogen Helicobacter pylori.
Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats.
Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats.
Piperine, the potential functional food for mood and cognitive disorders.
Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics.
Antioxidant activity of Cinnamomum cassia.
Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria.
Potentiation of antifungal activity of amphotericin B by essential oil from Cinnamomum cassia.
Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats.
Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb).
Pharmacological studies of cardamom oil in animals.
Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats.
The effect of citrus flavonoids on the redox state of alimentary-induced fatty liver in rats.
Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice.
Effect of licorice on the reduction of body fat mass in healthy subjects.
Antibacterial Activity of Medicinal Plants Against Pathogens causing Complicated Urinary Tract Infections.
Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats.
Anxiolytic and antiemetic activity of Zingiber officinale.
Component of Zingiber officinale that improves the enhancement of small intestinal transport.
Ginger: an ancient remedy and modern miracle drug.
Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori.
Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials.
Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys nigra var. Henonis leaf extract in vitro.
Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice.
The sacred lotus (Nelumbo nucifera) - phytochemical and therapeutic profile.
Diabetes and Metabolic Syndrome Research
Weight of the Obesity Epidemic. Rising Stroke Rates Among Middle-Aged Women in the United States.
Prevalence of Obesity, Type II Diabetes Mellitus, Hyperlipidemia, and Hypertension in the United States: Findings from the GE Centricity Electronic Medical Record Database.
Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study.
Effects of soluble sodium alginate on cholesterol excretion and glucose tolerance in rats.
Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice.
Chromium and polyphenols from cinnamon improve insulin sensitivity.
Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat.
The metabolic syndrome: definition, global impact, and pathophysiology.
Chromium in metabolic and cardiovascular disease.
Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle.
Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive rats.
Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid.
Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts.
Alpha-lipoic acid supplementation and diabetes.
Role of antioxidant activity of taurine in diabetes.
The effects of taurine, taurine homologs and hypotaurine on cell and membrane antioxidative system alterations caused by type 2 diabetes in rat erythrocytes.
Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus.
Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits.
The protective effects of taurine against early renal injury in STZ-induced diabetic rats, correlated with inhibition of renal LOX-1-mediated ICAM-1 expression.
Effects of taurine on the reactivity of aortas from diabetic rats.
Taurine supplementation and diabetes mellitus.
Complementary and alternative medicine for the treatment of type 2 diabetes.
Gymnema sylvestre for diabetes mellitus: a systematic review.
Gymnema sylvestre: A Memoir.
Systematic review of herbs and dietary supplements for glycemic control in diabetes.
Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice.
Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability.
The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance.
From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark.
Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats.
Cinnamon: Potential Role in the Prevention of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes.
Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice.
Ameliorative effect of the cinnamon oil from Cinnamomum zeylanicum upon early stage diabetic nephropathy.
Effect of cinnamon on glucose control and lipid parameters.
Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients.
Cinnamon improves glucose and lipids of people with type 2 diabetes.
A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects.
Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients.
A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers.
Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil.
Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.
Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats.
Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin secretion.
Ulcer healing properties of ethanolic extract of Eugenia jambolana seed in diabetic rats: study on gastric mucosal defensive factors.
Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats.
Effect of Eugenia Jambolana seed kernel on antioxidant defense system in streptozotocin-induced diabetes in rats.
Protective effect of a poly-phytocompound on early stage nephropathy secondary to experimentally-induced diabetes.
Therapeutic potential of ginseng root preparations in treating diabetes mellitus
Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice.
Korean red ginseng stimulates insulin release from isolated rat pancreatic islets.
Puerarin Inhibits C-Reactive Protein Expression via Suppression of Nuclear Factor kappaB Activation in Lipopolysaccharide-Induced Peripheral Blood Mononuclear Cells of Patients with Stable Angina Pectoris.
Yam contributes to improvement of glucose metabolism in rats.
Effects of different types of yam (Dioscorea alata) products on the blood pressure of spontaneously hypertensive rats.
Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents.
Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.
Effect of Astragalus membranaceus in rats on peripheral nerve regeneration: in vitro and in vivo studies.
Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.
Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.
Submerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats.
Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats.
Compare activities on regulating lipid-metabolism and reducing oxidative stress of diabetic rats of Tremella aurantialba broth's extract (TBE) with its mycelia polysaccharides (TMP).
Polysaccharides in fungi. XXXIII. Hypoglycemic activity of an acidic polysaccharide (AC) from Tremella fuciformis
Antidiabetic effect of an acidic polysaccharide (TAP) from Tremella aurantia and its degradation product (TAP-H).
Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin.
Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia.
Detoxification Research
Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification--five case reports.
Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication: cadmium and lead distribution and analysis in different mice organs.
Effect of garlic on lead contents in chicken tissues.
A study on the effect of garlic to the heavy metal poisoning of rat.
Comparative evaluation of adenosine deaminase activity in cerebral cortex and hippocampus of young and adult rats: effect of garlic extract (Allium sativum L.) on their susceptibility to heavy metal exposure.
Protective effects of garlic juice against embryotoxicity of methylmercuric chloride administered to pregnant Fischer 344 rats.
Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum sativum.
Prophylactic Efficacy of Coriandrum sativum (Coriander) on Testis of Lead-Exposed Mice.
Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats.
Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice.
Thiol-based antioxidants.
Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.
Heavy metal poisoning: management of intoxication and antidotes.
Lead exposure: a contributing cause of the current breast cancer epidemic in Nigerian women.
Protective effects of selenium on fluoride induced alterations in certain enzymes in brain of mice.
Detoxification of mercury by selenium by binding of equimolar Hg-Se complex to a specific plasma protein.
Identification of hepatoprotective flavonolignans from silymarin.
Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage.
Effects of Ginkgo biloba in dementia: systematic review and meta-analysis.
Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.
Prostate Cancer Research
ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in Human and Mouse Androgen-Dependent and -Independent Prostate Cancer Cells
Modified citrus pectin enhances the effect of novel dietary supplement formulas inhibition of invasiveness of breast and prostate cancer cells by down-regulation of urokinase plasminogen activator (uPA) secretion
The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development.
3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.
3,3'-Diindolylmethane enhances taxotere-induced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation.
3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status.
Inactivation of uPA and its receptor uPAR by 3,3'-diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migration.
Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells.
Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer.
Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer.
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways.
Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells.
3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.
Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells.
Vitamin D and prostate cancer: The role of membrane initiated signaling pathways in prostate cancer progression.
Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men.
Bone health in the prostate cancer patient receiving androgen deprivation therapy: a review of present and future management options.
