New Breakthrough Study: Modified Citrus Pectin Boosts Chemo’s Power against Ovarian Cancer
Ovarian cancer is one of the deadliest cancers because it’s often detected at a late stage, with higher risk of resistance to frontline chemotherapy drugs such as paclitaxel (commonly sold as Taxol). However, a new preclinical study from the University of Tehran and the Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, published in the Asian Pacific Journal of Cancer Prevention showed that Modified Citrus Pectin (MCP) increased the effectiveness of paclitaxel against ovarian cancer cells. Results showed MCP worked through its ability to block excess galectin-3 proteins.
This study furthers our understanding of how excess galectin-3 fuels the growth and spread of chemo-resistant cancer. The study showed for the first time that galectin-3 increases ovarian cancer cell proliferation and adhesion to collagen, and further substantiated previous findings that galectin-3 prevents apoptosis in cancer cells. (Apoptosis is the normal programmed cell death in a cell’s life cycle.) Moreover, the study showed that inhibition of galectin-3 by MCP sensitizes ovarian cancer cells to the chemotherapy drug. The anti-apoptosis effect of galectin-3 was reversed in the presence of MCP.
This study demonstrated that MCP may be a useful therapeutic agent in combination therapy for ovarian cancer. The authors note, “As paclitaxel has serious side effects, any agent that may lead to more effective cytotoxic effect or use of lower dose of this agent may be an interesting candidate for combination therapy. Our study demonstrated that MCP can sensitize ovarian cancer cells to paclitaxel through inducing apoptosis, suggesting that the combined use of MCP and paclitaxel may be an effective way to decrease the dose of paclitaxel taken.”
As research into galectin-3 continues, MCP gains further recognition as an effective natural galectin-3 inhibitor, shown in preclinical and clinical studies to block the growth and spread of prostate, breast, and other types of cancer. MCP has also been shown to work synergistically with other anti-cancer drugs, increasing the effectiveness of doxorubicin, cisplatin, dexamethasone, as well as botanical therapies for both breast and prostate cancer.
Read the full text study here: Synergistic Effects of PectaSol-C Modified Citrus Pectin an Inhibitor of Galectin-3 and Paclitaxel on Apoptosis of Human SKOV-3 Ovarian Cancer Cells. Hossein G, Keshavarz M, Ahmadi S, Naderi N. Asian Pac J Cancer Prev. 2013;14(12):7561-8.
New Study Demonstrates Natural Agent Protects Against Heart Disease
Santa Rosa, CA (11/20/2012) –
Cardiovascular disease will kill nearly 2.5 million people in the United States this year, according to the Centers for Disease Control. Over time, inflammation, collagen deposition and scar tissue formation can cause blood vessels to stiffen, a process called vascular fibrosis. Though researchers have known that the hormone aldosterone (Aldo) plays a role in this process, the precise mechanisms have been poorly understood.
Now, an international study published in Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association is providing new insights into cardiovascular disease.Particularly significant, the study illuminates how Aldo and the protein galectin-3 jointly contribute to vascular remodeling and congestive heart failure by fueling the processes of inflammation, fibrosis and collagen deposition. (more…)
San Francisco, CA (Nov. 5, 2012) – A unique formula made from medicinal mushrooms, traditional Chinese herbs and other natural ingredients inhibits aggressive, human triple-negative breast cancer and breast-to-lung metastasis in mice. This is the third peer-reviewed study to demonstrate the botanical formula’s anticancer effects.
The formula decreases metastasis, slows cancer growth and suppresses a number of pro-cancer genes, with no signs of toxicity. This study was conducted at the Cancer Research Laboratory, Methodist Research Institute, Indiana University Health. Results were published in the October 2012issue of Oncology Reports. (more…)
Latest Data Shows How Botanical Formulas Safely Fight Cancer and Metastasis
Santa Rosa, California (Oct. 16, 2012) – In the battle against cancer, some of the most remarkable weapons are proving to be specialized botanical supplements. Recently, a significant and growing body of scientific data was presented to over 200 oncologists and doctors, demonstrating the anti-cancer benefits of three unique botanical supplements: A breast formula; a prostate formula, and a preparation called Modified Citrus Pectin (MCP) derived from citrus peels. Researchers investigating these specialized supplements have found they suppress cancer invasiveness, modulate the expression of cancer cell cycle genes and decrease metastasis – without leading to toxic side effects. (more…)
Tel Aviv, Israel (Sept. 25, 2012) – More than 100 people attended a recent meditation retreat in Tel Aviv, Israel: Physicians, journalists, holistic practitioners, cancer patients and meditation enthusiasts. They came to learn holistic, mind-body approaches to healing and find avenues to spiritual growth. The retreat was led by integrative medicine pioneer and meditation expert Isaac Eliaz, M.D., L.Ac. and was coordinated by Taatsumot, a non-profit organization. The in-depth, two-day retreat program focused on the mind’s innate healing power.
Open Heart Healing
“The theme of my retreat is connectivity and having an open heart,” says Dr. Eliaz. “The heart has no concepts. It’s our mind, our negative emotions, our thought patterns that put up barriers and don’t allow our heart to just open. Real healing begins, continues and ends with an open heart.” (more…)
American Chemical Society Highlights Modified Citrus Pectin as Solution to Chronic Disease Marker Galectin-3
San Francisco, California (Aug. 23, 2012) – Cancer, heart disease, chronic inflammation — these disease conditions plague humanity, causing early death and untold suffering. Slowly, scientists are uncovering their numerous causes including genetic anomalies, environmental toxins, obesity and other factors. However, a rapidly expanding body of research points to a single biological culprit that profoundly affects these and other conditions—the molecule Galectin-3.
Presented at the Annual American Chemical Society Meeting
On August 21, integrative medicine expert, Isaac Eliaz, M.D., presented breakthrough research on Galectin-3 and Modified Citrus Pectin (MCP), a therapeutic carbohydrate that helps deactivate this rogue molecule, at the prestigious 244th National Meeting & Exposition of the American Chemical Society (ACS). (more…)
A variety of natural compounds help pin down the escape artist
Santa Rosa, California (Aug. 20, 2012) – Cancer may be the Harry Houdini of diseases — it often finds devious ways to escape treatment. Because cancer disables our cellular quality control mechanisms, rampant mutations that cause tumor cells to grow uncontrollably can also generate resistance to anticancer drugs. Even if 99 percent of the tumor is destroyed, that 1 percent can come roaring back. How do we knock out that 1 percent? By attacking the cancer from multiple angles, using multiple treatments and strategies.
“We need to outsmart the cancer before it outsmarts us. To do this, we have to find ways to attack cancer from many angles, so it doesn’t have the opportunity to develop protective mutations,” says integrative medicine pioneer, Isaac Eliaz, M.D. (more…)
Natural Agent Makes Safer, Lower Chemotherapy Doses Possible
Santa Rosa, California ( July 18, 2012) – Doxorubicin (Dox) is an effective anti-cancer drug, but it’s also a very toxic one, causing severe heart and immune damage. The doses needed to impact tumors are not well tolerated by patients; however, researchers may have found an answer through combination therapy. A study published in the journal Cell Biology International has shown that combining Dox with the natural supplement Modified Citrus Pectin (MCP) increases the anti-cancer activity of Dox. This finding bodes well for prostate cancer patients, especially those too weak for normal chemotherapy regimens. Combination therapy may allow for lower doses of Dox with enhanced clinical impact and reduced toxicity. (more…)
Santa Rosa, California (May 30, 2012) – Recent news reports and scientific reviews warn that nuclear radiation exposure is more serious than we believed. Just recently, the UK Guardian published an article titled, “Fukushima reactor shows radiation levels much higher than thought.” Another recent story published in Scientific American, finds California kelp contaminated with elevated levels of radioactive iodine. A review from the Max-Planck Society estimates that the risks of another serious nuclear accident are significantly higher than previously thought. As reports continue to reveal elevated nuclear radiation levels in Japan and elsewhere, public concerns about the safety of Fukushima and other reactor sites are reignited. (more…)
Santa Rosa, California (May 24, 2012) – In a groundbreaking study, Modified Citrus Pectin (MCP), a highly researched natural compound enhanced the anti-cancer effects of two poly-botanical formulas. When co-administered with formulas that attack breast and prostate cancer, MCP significantly increased their anti-cancer action, further reducing metastasis in highly invasive breast and prostate cancer cells. The study was led by researchers at the Cancer Research Laboratory at Indiana University Health and Indiana University School of Medicine, and published in the peer review journal Integrative Cancer Therapies. (more…)