Modified Citrus Pectin Protects Against Vascular Hardening

Posted on Nov 21, 2012 | 26 comments

Modified Citrus Pectin Protects Against Vascular Hardening

New Study Demonstrates Natural Agent Protects Against Heart Disease

Santa Rosa, CA (11/20/2012) — 

Cardiovascular disease will kill nearly 2.5 million people in the United States this year, according to the Centers for Disease Control. Over time, inflammation, collagen deposition and scar tissue formation can cause blood vessels to stiffen, a process called vascular fibrosis. Though researchers have known that the hormone aldosterone (Aldo) plays a role in this process, the precise mechanisms have been poorly understood.

Now, an international study published in Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association is providing new insights into cardiovascular disease.Particularly significant, the study illuminates how Aldo and the protein galectin-3 jointly contribute to vascular remodeling and congestive heart failure by fueling the processes of inflammation, fibrosis and collagen deposition.

The findings indicate that galectin-3 is required for inflammatory and fibrotic responses to Aldo, suggesting a key role for galectin-3 in vascular fibrosis.  Equally important, the study proves that Modified Citrus Pectin (MCP), a preparation derived from the pith of citrus peels, prevents these effects by binding to galectin-3 and controlling Aldo induced elevated galectin-3 levels.

MCP is a form of citrus pectin modified to a specific molecular weight and structure for enhanced absorption and bioactivity. Regular pectin goes through the gastrointestinal tract unabsorbed, whereas MCP is readily absorbed and has been demonstrated in published research to perform multiple beneficial functions. MCP’s small molecular weight and unique structure allow it to bind and block excess galectin-3 throughout the body. Elevated serum galectin-3 has been linked to high mortality rates in heart failure and metastatic cancer. MCP slows cancer progression and metastasis, blocks inflammation, helps prevent fibrosis, and offers other critical benefits related to the inhibition of galectin-3. It also supports immunity and safely chelates heavy metals.

Aldo and Galectin-3

The researchers in this study sought to understand exactly how Aldo and galectin-3 work together to affect vascular remodeling. In small quantities, Aldo and galectin-3 perform necessary biological functions. Aldo regulates blood pressure and electrolyte balance; galectin-3 facilitates cell-to-cell communication and cell growth. However, high levels of Aldo are linked to arterial stiffness and heart failure. Similarly, high levels of galectin-3 play a direct role in chronic inflammation, fibrosis and subsequent tissue remodeling in the kidneys, liver, heart and other organs; as well as cancer formation and metastasis.

In 2011, the Food and Drug Administration approved a serum galectin-3 test to assess the risk and progression of congestive heart failure and heart disease. This test is widely available and covered by most health insurances for cardiovascular screening. Practitioners also use this test to assess the risk and progression of cancer and other galectin-3 related diseases.

Dr. Isaac Eliaz, a recognized expert in the field of galectin-3 and the use of Modified Citrus Pectin states, “The results of this study have enormous implications for the prevention and treatment of heart disease and fibrosis related conditions. Because it functions as an active, culprit biomarker, galectin-3 serves as a therapeutic target in multiple life-threatening conditions. According to the scientific literature, this is achievable with the oral application of MCP, a galectin-3 inhibitor without side effects. This approach offers a new solution to numerous chronic conditions related to inflammation, fibrosis and metastatic cancer for which there are limited conventional treatments.”

Study Details In the study, rats were given Aldo and sodium chloride salt, which increased blood pressure, inflammation, fibrosis and galectin-3 levels. Using MCP, the research team blocked excess galectin-3 with significant results. Collagen type 1 deposition, blood pressure, inflammation, fibrosis and aortic wall thickness were all reduced. Spironolactone, a pharmaceutical Aldo inhibitor, achieved similar results.

However, the side effects of spironolactone are significant while MCP is proven to achieve greater results without toxicity or side effects. Specifically, the MCP was shown to outperform spironolactone in a few key areas related to inflammation and fibrosis. MCP achieved better suppression of fibrotic markers. Importantly, MCP completely inhibited the cytokine interleukin-6 (IL-6) which plays a key role in inflammation, fibrosis, immune response and cancer/metastasis. Spironolactone only partially blocked the Aldo induced IL-6.

The team went on to test the impact of increasing Aldo in regular mice as well as in galectin-3 knockout mice unable to produce the protein. When given Aldo, the normal mice experienced the inflammation and overabundant collagen formation associated with vascular remodeling. However, the knock-out mice experienced no ill effects, supporting the conclusion that Aldo requires galectin-3 to induce the collagen type 1 synthesis and deposition associated with vascular fibrosis.

Beyond Heart Disease

This new research confirms a number of earlier studies which implicate galectin-3 in numerous conditions related to inflammation and fibrosis. In particular, it substantiates research published in the journal PLoS One in 2011 demonstrating the role that galectin-3 plays in acute fibrosis-related kidney injuries. That study also shows that MCP blocks the harmful effects of excess galectin-3 and helps to reverse related damages.

This recent study marks a critical step toward understanding the mechanisms behind vascular fibrosis, and the role MCP can play in inhibiting these and other factors associated with heart failure and organ fibrosis. More research must be done to further illuminate the role of galectin-3 in cardiovascular and chronic diseases. Further research including clinical trials are being planned to explore MCP as a safe and natural preventative and treatment for congestive heart failure and metastatic cancer.

For more information on modified citrus pectin call (707) 583-8619, or visit www.mcprecommends.org

Source: Galectin-3 mediates aldosterone-induced vascular fibrosis. Laurent C, Maria M, Pascal R, Victoria C, Ernesto MM, de Boer RA, Françoise P, Patrick L, Faiez Z, Patrick R, Natalia LA.Arterioscler Thromb Vasc Biol. 2012 Nov 1. [Epub ahead of print]

 

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26 Comments

  1. interesting article. are there any studies on Scleraderma or pulmanary fibrosis. I would like to get involved or get up dates on research studies or new information out there.
    Thanks

    Dave

  2. It seems evident that insights into the causes of disease, above all inflammation, and the favorable impact of MCP may develop into one of the most significant developments for the maintenance of good health.

  3. What was the daily dosage of MCP? The article didn’t state that important factor. I take 5 grams twice a day.

    • Recommended MCP Dosages
      For active cancer: 15 grams MCP/day (5 grams three times a day on an empty stomach).
      For biopsy patients: 15 grams MCP/day (5 grams three times a day on an empty stomach) for one week before the procedure and at least two weeks after.
      For cancer prevention: 5 grams MCP/day (on an empty stomach on an ongoing basis).

    • Science has taught us that animals that produce their own vitamin C produce as much as needed for their body size and produce even more when under stress. In comparison for a human weighing 150 lbs. that person would need at least 10 grams or 10,000 kilo grams of vitamin C a day. 15 grams a day would be a better bet.
      It may take awhile with bowel adjustments to get up to 15 grams a day. Vitamin C has a tendancy to loosen the stools, so at that point stop and cut back a little, until the body adjust to the ‘natural’ (not ascorbic synthetic) vitamin C increase, and slowly work up to the 15 grams a day. Your arteries, main internal organs, and that no longer aging skin will love you for it.

  4. I have a comment. Recently my Galectin level was 27. I currently am a healthy 53 year old with no chronic health concerns, obesity, or heart disease. I am taking MCP twice a day. At what level should I be evaluated for heart disease? Thank you for a reply
    Joy

    • Your articles are very informative,
      I a going to keep on reading.

  5. Please, let me know how doctors check Galectin content? Is this procedure a routine check up? My husband passed all the tests (blood, cardio etc) regarding chest pain at night and he was found normal. Why don’t they send him for Galectin level checkup? What is normal level ?

    • The Galectin-3 blood test was developed by BG Medicine and is available through Health Diagnostic Laboratory, Inc. To order the test you can call client services at 1-877-433-5227 and they will send out all the necessary instructional materials to you and your physician. The ideal level is from 12.0 to 14.0.

      We hope this helps. Thank you for your question!

      The DrEliaz.org Blog Staff

  6. I remember reading many, many years ago about the benifits of pith of citrus peels. It was said that it would get rid of varicose and spider veins, so it make sense that Modified Citrus Pectin (MCP), would help in the healing of inflamed arteries.
    Dr. Matthias Rath who worked with Dr. Linus Pauling for awhile showed Dr. Pauling how vitamin C will help stop plaque from sticking to the arteries. Dr. Pauling studied his work and agreed on his findings.
    It is a shame that over 85% of the vitamin C sold in the US is synthetic ascorbic acid, and mostly imported from China. And we all know what a lousy quality control track record China has had had in the past.
    Natural vitamin C such as Modified Citrus Pectin is a good way to go.

  7. Thank you for more info re MCP, Galectin-3, and aldosterone! I have already noticed that only 1 month of MCP and my lab values for kidney function, Glomerular Filtration Rate, increased from 80 to 90. If I don’t take herbal diuretics, my value is naturally at about 70, increases to 80 with herbs. You can imagine my delight to see rapid improvement with MCP. I also have 2 disadvantaged alleles for aldosterone gene, with enlarged veins on hands since age 29.

    Have struggled with oral biofilm for past 10 years. Oral DNA testing indicates antibiotic resistant bacteria. Suggested antibiotics have not helped. Great news to learn MCP will address this issue, too! Many thanks, Dr. Eliaz!!

  8. I forgot to add that within this same first month my hearing improved dramatically. When my son gifted me iPod & iPad 2010, I used to push earbuds into my ear “trying” to hear the music. Soon after starting MCP I was startled by sound blasting into my ears. This is indeed a precious gift! Thanks, again!!

  9. It’s very easy to find out any matter on net as compared to textbooks, as I found this post at this site.

  10. Its like you read my thoughts! You seem to understand a lot about this, like you wrote the ebook in it or something.
    I feel that you can do with some p.c. to pressure the
    message home a bit, but other than that, this is magnificent blog.
    A fantastic read. I will certainly be back.

  11. This is an interesting study if you are a rat. I would like to see a human study that shows the same benefits.

  12. Please can you tell me the dosage of MCP capsules? I am 35 years old, I have multiple food sensitivities and suffer from bile reflux. The only indications on the back at the bottle is 6 capsules three times daily so I am currently taking 18 capsules a day. It seems a lot. Would 6 capsules be enough in my case? Or if it’s 18 can I open them and melt them in water? Thank you for your time. Claudia

    • The dosage of 18 capsules is the active dosage for serious, on-going health issues or heavy metal detoxification. Six capsules is the maintenance dosage which does sound appropriate for you. You may open the caps and dissolve the powder in water, juice, tea or coffee. Also for any future orders please know that MCP is available in powder form.

      – Dr. Eliaz Staff

  13. Thank you very much for your reply. I have one last question. Is pectasol or pectaclear safe to use during pregnancy? Which ones of your products are safe to use during pregnancy? Thank you so much for your work and for your time.

    • None of our products have been tested for use during pregnancy.

  14. “Citrus Pectin is a highly binding material that joins with cholesterol and bilious acids before they are absorbed in the body and swiftly eliminates them from the intestinal tract. The large size and molecular weight of Citrus Pectin is said to benefit the digestive tract by cleansing the intestinal tract”. Can you confirm that this is also the case for Modified Citrus Pectin? It is quite important as I know the molecular weight of MCP is reduced and therefore for people like me, who suffer with bile reflux, it’d be helpful to know if Pectasol actually binds with bilious acids. If you can clarify this I would really appreciate it!

    • Modified citrus pectin has a range of molecular weight, but overall much lower than regular pectin, which does interact with bile compounds. There may be some interaction with a small fraction of the modified citrus pectin that is not absorbed into the circulation. Most of it is absorbed in the small intestine.

  15. Thank you for all your answers.

  16. In the study it states that MCP is more effective than spironolactone. My question is, I am taking spironolactone for PCOS – would I be able to take the MCP for this treatment and achieve the same results without taking this synthetic chemical into my system amy longer? Also, do you have any suggestions for us out there suffering with PCOS and how we can treat it and the side effects in a natural way versus the drugs currently prescribed?

    I look forward to your answer. Thank you.

    • Thank you for your great questions. We are not able to specifically address medical questions on this site. However the following information may be of help. MCP is not a drug and does not have the same mechanism of action as spironalactone, although they both have some common effects in the sense that they both are inhibitors of galectin-3, which is an inflammatory protein that promotes fibrosis and therefore damage to the cardiovascular system. This is not the primary function of this drug for PCOS. It is an anti-androgen (as well as having other effects like reducing blood presssure) which reduces the effects of male (androgenic) hormones, which tend to be elevated in PCOS and can cause unwanted hair growth.

      PCOS is also related to insulin resistance and metabolic syndrome. This tendency can be addressed naturally and there are a number of nutrients and herbs that help. A healthier metabolism can reduce some of the hormone imbalances that come with PCOS. More information can be found on dreliaz.org where you can download a Metabolic Health Guide. http://www.dreliaz.org/wellness-guide/metabolic/

  17. In all of your discussion here I have not seen anything about drug interactions such as blood pressure meds or colesteral meds.. I take both.. crestor for cholestrol and licinopril for blood pressure. iam 62 years old and am in good health but had a heart attack 4 years ago and am doing great on my LDL (84)and HDL (65)blood work . would like to know if I should be tested for what my galectin-3 levels are .. and if MCP would benefit me for cardio vascular disease… Thank you…

    • Thank you for your questions. There is a large body of research and more every day on the correlations between galectin-3 and risk of cardiovascular disease as well as monitoring people with existing cardiovascular disease. It is another level of information which can help guide preventative care. MCP has been shown to block galectin-3 which is both a marker and a promoter of inflammation and the development of fibrosis in tissues including the heart and blood vessels. You can find more research articles at the link http://www.dreliaz.org/research-library/. Although we are not able to comment on a particular disease process, MCP definitely supports healthy cardiovascular functioning. Galectin-3 testing is now widely available through Lab Corps nationwide. Best of Health

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